Good question (how DO you find synergy?). Recently I've been studying the electrical equivalent circut model of the COMPLETE amp signal/driver/enclosure/accoustic wave electro-mechanical system (presented in "An Electroacoustic Analysis of Transmission Line Loudspeakers" PHD dissertation by R. A. Robinson, Jr. - link posted to "over there" by RichP) and was "dreaming" about how to adapt those equations to a software package that would in essence allow one to analytically produce frequency response curves from different "tweaks" of a basic system (or in my case also use it to determine "optimal" speaker enclosure volumns, driver sizes, and internal speaker damping material packing densities - all of which effect overall system response). This paper also presents experimental ways to determine the key mechanical/electrical properties of the LF drivers used in your system. My thoughts were that one could also obtain (either thru measurement or from company provided spec sheets) the R/C/L parameters of different "high end" speaker wire brands (vs frequency) and it would be a very easy matter to add these circut element parameters vs freq to the overall circut model of one's entire system (starting with an "ideal" input signal vs frequency and then generating the sound pressure level (SPL) vs frequency plot of the loudspeaker and "adjusting" the speaker wires and - if building/designing speakers - also adjusting enclosure volumn, driver size, packing densities, etc. until one obtains the flatest LF frequency response of this overall system). The resulting complex circut model is just solved (in this case for the SPL at the speaker exit plane) by existing "circut solver" software packages with the desired mechanical system quantities analogously represented in the complex circut model as either voltages or currents. Granted, models can't model everything, but they are very good at tracking the DIFFERENCES in system response for each trial configuration and thus determining the "optimal" set of speaker wire "brand" and/or the optimal speaker design. Of course everything "upstream" of this (the source, the IC's, the preamp, the amp) is still "variable" and pretty much a matter of personal preferences, but I believe everything "downstream" of this (i.e., the speaker wires and speakers themselves) should be as "flat" and nuetral as possible with the lowest frequency response possible before the ~3 db drop off of the SPL..... All of this can be optimized based on the aforementioned "design parameters" (including the different R/C/L parameters vs frequency of the various "high end" speaker wires available for one to choose from).
Family room: 400 disk changer with PS Audio Digital Link III DAC; Technics SL-1100A TT. QED Quenx1 IC's from DAC & TT to Adcom GTP-602 preamp/Tuner. AudioQuest King Cobra IC's from preamp to M1.0t mk-II opt2. QED Silver Spirals 4M wires to EPI 1000’s.
Living room: AudioQuest Black Mamba 8M IC's from family room preamp to Barcus-Berry 2002R Sonic Maximizer to GlowPower Zyxt IC's to Sunfire 300x2 to Nordost 6M bi-source wires to AOS 28" MDF spherical speakers using six 8" woofers and eight 1" dome tweeters symm. arranged around the surface.
SS system: CX-995V DVD to AV-705x 5 channel amp (center/rears) & M1.0t mk-II opt2(fronts).
Garage: TLM-3600 CDP to MXR150 Receiver (pre) to TFM-42 to EPI 400 speakers.